Steven T. DeKosky, MD, Chief of the Cognitive and Behavioral Neurology Division, directs the NIA-funded Alzheimer’s Disease Research Center and conducts experimental therapeutic studies of Alzheimer’s disease and mild cognitive impairment. In another grant from the National Institute on Aging, he studies neurochemical and structural changes in the brains of people with very early changes in cognition (a precursor to dementia or Alzheimer’s disease), and the relation between head trauma and Alzheimer’s disease in a grant from the NINDS. As a behavioral neurologist/ geriatric neuropsychiatrist, he has moved toward intervention trials in dementia and the design and execution of medication trials in symptomatic Alzheimer’s disease and its prevention. He directs an NIH-funded 3000 person multi-center national trial of Ginkgo biloba in the prevention of dementia. Dr. Oscar Lopez’s main area of concentration is Alzheimer’s disease research and AIDS dementia. He is associate director of the ADRC clinical core. Dr. Lopez is also co-investigator in the Ginkgo Biloba Prevention trial in Older Individuals and HIV1- Related Neuropsychological Abnormalities. He leads an NIH-funded study examining predictors of Alzheimer’s disease in mild cognitive impairment (MCI). His recent findings are relevant to our understanding of the symptom profile and nosology of MCI. Dr. Judith Saxton, PhD focuses her research on the assessment of older patients with cognitive problems. She is the principal investigator of a new NIA-funded grant that investigates the utility of cognitive testing in the primary care setting by using computer tests to identify older patients with mild cognitive impairment. In addition she is a co-investigator on a number of studies including the ginkgo biloba trial and the PIB-PET imaging program project grant and will lead the community initiative for the Commonwealth of Pennsylvania Center of Excellence in the Detection, Diagnosis and Intervention in Dementia. She also is an associate director of the clinical core of the Alzheimer Disease Research Center and the core leader of the training and information core. Dr. David Wolk, who joined the Department in February 2006, is a behavioral and cognitive neurologist principally interested in episodic memory processes and the impact of aging and Alzheimer’s disease on memory function. Dr. Wolk is currently funded with an NIA ADRC pilot study.