Associate Professor of Neurology, Molecular Genetics and Biochemistry
Neurology appointments: 412-692-4920
Movement disorders clinic and patient inquiries: 412-692-4670
PIND (research laboratory): 412-648-9720
Edward Burton, MD, graduated Bachelor of Medicine and Surgery with Honors from the
University of Birmingham Medical School, England, UK in 1991. He completed a general
medicine residency in Oxford, UK and was admitted to Membership of the Royal College
of Physicians in 1994. After neurology residency training in Birmingham, UK, he
became a research training fellow at the University of Oxford, graduating Doctor
of Philosophy in 2000. A postdoctoral fellowship in neurological gene transfer carried
out at the University of Pittsburgh led to the degree of Doctor of Medicine with
Honors from the University of Birmingham, England, UK, in 2003. He completed higher
specialist training in neurology as Clinical Lecturer in Neurology at the University
of Oxford, and was admitted to the specialist register of the General Medical Council
(UK) in 2003. Between 2003 and 2004 he completed a clinical fellowship in movement
disorders at the National Hospital for Neurology and Neurosurgery, Queen Square,
London. Dr. Burton was elected to Fellowship of the Royal College of Physicians
of London in May 2009.
Dr. Burton joined the faculty of University of Pittsburgh in 2004 and is currently
Associate Professor of Neurology. He divides his time between providing clinical
care to patients with movement disorders in the comprehensive movement disorders
clinic at UPMC, carrying out research into neurodegeneration in the Pittsburgh Institute
for Neurodegenerative Diseases, and teaching in the medical school.
Dr. Burton's publications can be reviewed through the National Library
of Medicine's publication database.
Parkinson’s disease and related disorders, including progressive
supranuclear palsy, multiple system atrophy and corticobasal degeneration; Tremor;
Dystonia; Botulinum toxin treatment for focal dystonia, sialorrhoea and hemifacial
Research Interests and Representative Recent Publications
Mechanisms and neuroprotection in neurodegenerative diseases, using novel zebrafish
models and viral gene transfer.
Bai, Q., Garver, J. A., Hukriede, N. A., Burton, E. A. (2007). Generation
of a transgenic zebrafish model of Tauopathy using a novel promoter element derived
from the zebrafish eno2 gene. Nucleic Acids Res. 35 (19), 6501-16
Bai, Q., Wei, X., and Burton, E. A. (2009). Expression of a 12kb promoter
fragment derived from the zebrafish enolase-2 gene in the zebrafish visual system.
Neurosci Lett. 449(3), 252-7.
Bai, Q. and Burton, E. A. (2009). Cis-acting elements responsible for dopaminergic
neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in
vivo are located remote from the transcriptional start site. Neuroscience.
Cannon, J., Sew, T., Montero, L., Burton, E. A., and Greenamyre, J. T. (2011). Pseudotype-dependent
lentiviral transduction of astrocytes or neurons in the rat substantia nigra. Experimental
Neurology. 228(1), 41-52
Van Laar, V. S., Arnold, B. A., Cassady, S. J., Chu, C. T., Burton, E. A., and Berman,
S. B. (2011). Bioenergetics of neurons inhibit the translocation response of Parkin
following rapid mitochondrial depolarization. Human Molecular Genetics. 20(5),
Bai, Q., Sun, M., Stolz, D. B., Burton, E. A. (2011). The major isoform of zebrafish
P0 is a 23.5kDa myelin glycoprotein expressed in selected white matter tracts of
the central nervous system. Journal of Comparative Neurology. 519(8),1580-96
Horowitz, M., Milanese, C., Di Maio, R. Hu, X., Montero, L. M., Sanders, L., Tapias,
V., Sepe, S., van Cappellen, G., Burton, E. A., Greenamyre, J. T., Matsroberardino,
P. G. (2011) Single-cell redox imaging demonstrates a distinctive response of dopaminergic
neurons to oxidative insults. Antioxidants & Redox Signaling. 15(4), 855-71.
Cario, C. L., Farrell, T. C., Milanese, C. and Burton, E. A. (2011). Automated measurement
of zebrafish larval movement. The Journal of Physiology. 589(15), 3703-8.
Farrell, T. C., Cario, C. L., Milanese, C., Vogt, A., Jeong, J.-H., Burton, E. A.
(2011) Evaluation of spontaneous propulsive movement as a screening tool to detect
rescue of Parkinsonism phenotypes in zebrafish models. Neurobiology of Disease.
44(1), 9-18. [Featured on the cover of the October 2011 issue of NBD]
Münzel, E., Schaefer, K., Obirei, B., Kremmer, E., Burton, E. A., Kuscha, V., Becker,
C. G., Brösamle, C., Williams, A., Becker, T. (2012) Claudin k is specifically expressed
in cells that form myelin during development of the nervous system and regeneration
of the optic nerve in adult zebrafish. Glia. 60(2):253-70
Milanese, C., Sager, J. J., Bai, Q., Farrell, T. C., Cannon, J. R., Greenamyre,
J. T., Burton, E. A. (2012) Hypokinesia and reduced dopamine levels in zebrafish
lacking β- and γ1-synucleins. J Biol Chem. 287(5):2971-83 [Featured on the cover
of the January 27, 2012 issue of JBC]
Sager, J.J., Torres, G.E., Burton, E. A. (2012) The zebrafish homologue of the human
DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early
motor system development. PLoS ONE. 7(9):e45175
Research Grant Support
Dr. Burton’s research is currently supported by:
- The National Institute of Environmental Health Sciences
- The National Institute of Neurological Disorders and Stroke
- The National Science Foundation
- The Department of Veterans' Affairs
- The Ethel Vincent Charitable Trust
- The Blechman Foundation
- The Bachmann-Strauss Foundation