Professor of Neurology,
University of Pittsburgh School of Medicine
Department of Neurology
8096 Forbes Tower
Pittsburgh, PA 15213
Clinical Appointments: (412) 692-4920
Specialized Areas of Interest
Dr Pan’s laboratory focuses on brain metabolism, bioenergetics and the use of ultra-high field (7T and 3T) magnetic resonance (MR) spectroscopic imaging for its assessment, with applications in epilepsy and other neurological disorders. Projects in the laboratory have included the non-invasive MR-based assessments of human cerebral ketone body physiology, mitochondrial energetics, and currently focus on implementing ultra-high field metabolic imaging to help localize and lateralize seizure onset in patients suffering from partial onset epilepsy. The newest project undertaken in the laboratory focuses on implementing a rat model of epilepsy with spectroscopic imaging at 7T to assess the metabolic pathophysiology of epileptogenesis. Given the metabolic dysfunction and the disturbances in excitatory and inhibitory neurotransmission that are highly prevalent in epilepsy, we anticipate that this rodent project may help define the imaging biomarkers of epileptogenesis. With ongoing parallel human imaging studies, we believe that this work will provide an assessment of the metabolic contribution towards epilepsy, and also a direct approach to the evaluation and management of epilepsy patients.
Funding sources are currently NIH R01 EB011639 and R21 NS083035, and in the past have included the Swebilius Foundation and Dana Foundation.
- Pan JW, Bebin EM, Chu WJ, Hetherington HP. Ketosis and epilepsy: 31P spectroscopic imaging at 4.1T. Epilepsia 1999 40(6):703-7.
- Pan JW, de Graaf RA, Petersen KF, Shulman GI, Hetherington HP, Rothman DL. [2,4-13C2]-b-hydroxybutyrate metabolism in human brain. J Cereb Blood Flow Metab 2002 22(7):890-8.
- Pan JW. Insights from neuroimaging studies into ketosis and the ketogenic diet. In, The ketogenic diet, Humana Press, Eds CE Stafstrom and J Rho Sept 2004.
- Williamson A, Patrylo P, Pan JW, Spencer DD, Hetherington HP. Correlations between granule cell physiology and bioenergetics in human temporal lobe epilepsy. Brain 2005 128(5):1199-208.
- Pan JW, Takahashi K. Inter-dependence of NAA and high energy phosphates in human brain. Ann Neurol. 2005 57(1):92-97.
- Pan JW, Duckrow RB, Spencer D, Avdievich N, Hetherington HP. Spectroscopic imaging of GABA in human brain at 7T. Magn Res Med Epub Early View 11 April 2012
- Hetherington HP, Hamid H, Kulas J, Ling G, Bandak F, de Lanerolle N, Pan JW. MRSI of Medial Temporal Lobe at 7T in Blast Related Mild Traumatic Brain Injury. Magn Res Med December 2012